Publications

2022

• He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christian E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK. Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function. Immunity. 2022 Jan 11;55(1):159-173.e9. PMID: 34982959; PMCID:PMC9074730.
• Purohit V, Wagner A, Yosef N, Kuchroo VK. Systems-based approaches to study immunometabolism. Cell Mol Immunol. 2022 Mar;19(3):409-420. PMID: 35121805; PMCID: PMC8891302.
• Kuchroo VK, Weiner HL. How does Epstein-Barr virus trigger MS? Immunity. 2022 Mar 8;55(3):390-392.
• Tang R, Acharya N, Subramanian A, Purohit V, Tabaka M, Hou Y, He D, Dixon KO, Lambden C, Xia J, Rozenblatt-Rosen O, Sobel RA, Wang C, Regev A, Anderson AC, Kuchroo VK. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function. Sci Immunol. 2022 Mar 11;7(69):eabm0631. PMID: 35275752; PMCID: PMC9273260.
• Song Z, Yuan W, Zheng L, Wang X, Kuchroo VK, Mohib K, Rothstein DM. B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease. Front Immunol. 2022 Mar 14;13:762390. doi: 10.3389/fimmu.2022.762390. PMID: 35359977; PMCID: PMC8963939.
• Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nat Immunol. 2022 Apr;23(4):632-642. PMID: 35301508; PMCID: PMC8989655.
• Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2117065119. PMID: 35467979; PMCID: PMC9169934.
• Krovi SH, Kuchroo VK. Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases. Immunol Rev. 2022 May;307(1):161-190. PMID: 35142369; PMCID: PMC9255211
• Pagliano O, Morrison RM, Chauvin JM, Banerjee H, Davar D, Ding Q, Tanegashima T, Gao W, Chakka SR, DeBlasio R, Lowin A, Kara K, Ka M, Zidi B, Amin R, Raphael I, Zhang S, Watkins SC, Sander C, Kirkwood JM, Bosenberg M, Anderson AC, Kuchroo VK, Kane LP, Korman AJ, Rajpal A, West SM, Han M, Bee C, Deng X, Schebye XM, Strop P, Zarour HM. Tim-3 mediates T cell trogocytosis to limit antitumor immunity. J Clin Invest. 2022 May 2;132(9):e152864. doi: 10.1172/JCI152864. PMID: 35316223; PMCID: PMC9057587.
• Hernández-Malmierca P, Vonficht D, Schnell A, Uckelmann HJ, Bollhagen A, Mahmoud MAA, Landua SL, van der Salm E, Trautmann CL, Raffel S, Grünschläger F, Lutz R, Ghosh M, Renders S, Correia N, Donato E, Dixon KO, Hirche C, Andresen C, Robens C, Werner PS, Boch T, Eisel D, Osen W, Pilz F, Przybylla A, Klein C, Buchholz F, Milsom MD, Essers MAG, Eichmüller SB, Hofmann WK, Nowak D, Hübschmann D, Hundemer M, Thiede C, Bullinger L, Müller-Tidow C, Armstrong SA, Trumpp A, Kuchroo VK, Haas S. Antigen presentation safeguards the integrity of the hematopoietic stem cell pool. Cell Stem Cell. 2022 May 5;29(5):760-775.e10. doi: 10.1016/j.stem.2022.04.007. PMID: 35523139; PMCID: PMC9202612.
• Douna H, Smit V, van Puijvelde GHM, Kiss MG, Binder CJ, Bot L, Kuchroo VK, Lichtman AH, Kuiper J, Foks AC. Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis. Atherosclerosis. 2022 Jul;352:1-9. doi: 10.1016/j.atherosclerosis.2022.05.017. Epub 2022 May 21. PMID: 35636144.
• Meisgen S, Hedlund M, Ambrosi A, Folkersen L, Ottosson V, Forsberg D, Thorlacius GE, Biavati L, Strandberg L, Mofors J, Ramskold D, Ruhrmann S, Meneghel L, Nyberg W, Espinosa A, Hamilton RM, Franco-Cereceda A, Hamsten A, Olsson T, Greene L, Eriksson P, Gemzell-Danielsson K, Salomonsson S, Kuchroo VK, Herlenius E, Kockum I, Sonesson SE, Wahren-Herlenius M. Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function. Ann Rheum Dis. 2022 Aug;81(8):1151-1161. doi: 10.1136/annrheumdis-2021-221714. Epub 2022 Apr 25. PMID: 35470161; PMCID:
• Spiljar M, Kuchroo VK. Metabolic regulation and function of T helper cells in neuroinflammation. Semin Immunopathol. 2022 Sep;44(5):581-598. doi: 10.1007/s00281-022-00959-z. Epub 2022 Sep 6. PMID:
• Pawlak M, DeTomaso D, Schnell A, Meyer Zu Horste G, Lee Y, Nyman J, Dionne D, Regan BML, Singh V, Delorey T, Schramm MA, Wang C, Wallrapp A, Burkett PR, Riesenfeld SJ, Anderson AC, Regev A, Xavier RJ, Yosef N, Kuchroo VK. Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling. Immunity. 2022 Sep 13;55(9):1663-1679.e6. doi: 10.1016/j.immuni.2022.08.007. Epub 2022 Sep 6. PMID: 36070768; PMCID: PMC9808605.
• Pei W, Kuchroo VK. tRNA-m1A modification: a translational checkpoint for T cell expansion. Cell Res. 2022 Dec 22. doi: 10.1038/s41422-022-00764-1. Epub ahead of print. PMID: 36550269.

2021

• Thangavelu G, Wang C, Loschi M, Saha A, Osborn M, Furlan SN, Aoyama K, McDonald-Hyman C, Aguilar EG, Janesick AS, Chandraratna RA, Refaeli Y, Panoskaltsis-Mortari A, MacDonald KP, Hill GR, Zeiser R, Maillard I, Serody J, Murphy WJ, Munn DH, Blumberg B, Brown C, Kuchroo VK, Kean LS, Hippen K, Noelle RJ, Blazar BR. Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses. Blood. 2021 Feb 25;137(8):1090-1103. doi: 10.1182/blood.2020005628. PMID: 32976550; PMCID: PMC7907720.
• Mathias Pawlak, David DeTomaso, Gerd Meyer zu Horste, Youjin Lee, Jackson Nyman, Danielle Dionne, Chao Wang, Antonia Wallrapp, Patrick R. Burkett, Samantha J. Riesenfeld, Ana C. Anderson, Aviv Regev, Ramnik J. Xavier, Nir Yosef, Vijay K. Kuchroo. Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling. bioRxiv 2021.01.24.426445; doi: https://doi.org/10.1101/2021.01.24.426445
• Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS. Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Commun Biol. 2021 Mar 19;4(1):360. doi: 10.1038/s42003-021-01871-2. PMID: 33742094; PMCID: PMC7979749.
• Rudak PT, Choi J, Parkins KM, Summers KL, Jackson DN, Foster PJ, Skaro AI, Leslie K, McAlister VC, Kuchroo VK, Inoue W, Lantz O, Haeryfar SMM. Chronic stress physically spares but functionally impairs innate-like invariant T cells. Cell Rep. 2021 Apr 13;35(2):108979. doi: 10.1016/j.celrep.2021.108979. PMID: 33852855; PMCID: PMC8112805.
• Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JV. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021 May 4;33(5):1042-1061.e7. doi: 10.1016/j.cmet.2021.04.004. PMID: 33951465; PMCID: PMC8132466.
• Dixon KO, Tabaka M, Schramm MA, Xiao S, Tang R, Dionne D, Anderson AC, Rozenblatt-Rosen O, Regev A, Kuchroo VK. TIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Nature. 2021 Jul;595(7865):101-6. doi: 10.1038/s41586-021-03626-9. PMID: 34108686.
• Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 Jun 29:S0092-8674(21)00700-5. doi: 10.1016/j.cell.2021.05.045. PMID: 34216539.
• Anderson AC, Kuchroo VK. Introduction to the Special Issue: Immuno-oncology. Semin Immunol. 2021 Jul 1:101483. doi: 10.1016/j.smim.2021.101483.  PMID: 34219003.
• Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021 Aug 5;184(16):4186-4202.e20. doi: 10.1016/j.cell.2021.06.007. PMID: 34216540; PMCID: PMC8358979.
• Chen Z, Luo J, Li J, Kim G, Chen ES, Xiao S, Snapper SB, Bao B, An D, Blumberg RS, Lin CH, Wang S, Zhong J, Liu K, Li Q, Wu C, Kuchroo VK. Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion. J Exp Med. 2021 Sep 6;218(9):e20210324. doi: 10.1084/jem.20210324. Epub 2021 Jul 21. PMID: 34287641.

2020

• Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 Jan 9;180(1):33-49.e22. doi: 10.1016/j.cell.2019.11.014. Epub 2019 Dec 5. PMID: 31813624; PMCID: PMC6954329.
• Schnell A, Bod L, Madi A, Kuchroo VK. The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity. Cell Res. 2020 Apr;30(4):285-299. doi: 10.1038/s41422-020-0277-x. Epub 2020 Jan 23. Erratum in: Cell Res. 2020 Apr;30(4):285-99. PMID: 31974523; PMCID: PMC7118128.
• Wolf Y, Anderson AC, Kuchroo VK. TIM3 comes of age as an inhibitory receptor. Nat Rev Immunol. 2020 Mar;20(3):173-185. doi: 10.1038/s41577-019-0224-6. Epub 2019 Nov 1. PMID: 31676858.
• Wagner A, Wang C, DeTomaso D, Pacheco JA, Zaghouani S, Fessler J, et al. In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity. J Immunol [Internet]. 2020 May 1;204(1 Supplement):150.22 LP-150.22. Available from: http://www.jimmunol.org/content/204/1_Supplement/150.22.abstract
• Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VK. Checkpoint Receptor TIGIT Expressed on Tim-1⁺ B Cells Regulates Tissue Inflammation. Cell Rep. 2020 Jul 14;32(2):107892. doi: 10.1016/j.celrep.2020.107892. PMID: 32668241; PMCID: PMC7496220.
• Dixon KO, Kuchroo VK. IL-18: throwing off the shackles to boost anti-tumor immunity. Cell Res. 2020 Oct;30(10):831-2. doi: 10.1038/s41422-020-00396-3. PMID: 32811976;  PMCID: PMC7608459
• Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, Christian E, Ferreira M, Dixon KO, Fell G, Tooley K, Mangani D, Xia J, Singer M, Bosenberg M, Neuberg D, Rozenblatt-Rosen O, Regev A, Kuchroo VK, Anderson AC. Endogenous Glucocorticoid Signaling Regulates CD8⁺ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020 Sep 15;53(3):658-71.e6. doi: 10.1016/j.immuni.2020.08.005. PMID: 32937153.
• Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. bioRxiv [Preprint]. 2020 Oct 31:2020.10.30.362947. doi: 10.1101/2020.10.30.362947. PMID: 33140047; PMCID: PMC7605554.
• Hu D, Tjon EC, Andersson KM, Molica GM, Pham MC, Healy B, Murugaiyan G, Pochet N, Kuchroo VK, Bokarewa MI, Weiner HL. Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30639-48. doi: 10.1073/pnas.2007935117. Epub 2020 Nov 17. PMID: 33203678; PMCID: PMC7720234.
• Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, Christian E, Etminan Y, Lee A, Stroh H, Xia J, Karwacz K, Thakore PI, Acharya N, Schnell A, Wang C, Apetoh L, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 Nov 24;33(8):108433. doi: 10.1016/j.celrep.2020.108433. PMID: 33238123; PMCID: PMC7771052.
• Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK. T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 Dec 15;205(12):3247-62. doi: 10.4049/jimmunol.2000748. Epub 2020 Nov 9. PMID: 33168576; PMCID: PMC7725915.
• Pawlak M, Ho AW, Kuchroo VK. Cytokines and transcription factors in the differentiation of CD4⁺ T helper cell subsets and induction of tissue inflammation and autoimmunity. Curr Opin Immunol. 2020 Dec;67:57-67. doi: 10.1016/j.coi.2020.09.001. Epub 2020 Oct 8. PMID: 33039897; PMCID: PMC7747296.

2019

• Kurtulus S, Madi A, Escobar G, Klapholz M, Nyman J, Christian E, Pawlak M, Dionne D, Xia J, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1^–CD8⁺ Tumor-Infiltrating T Cells. Immunity. 2019 Jan 15;50(1):181-194.e6. doi: 10.1016/j.immuni.2018.11.014. Epub 2019 Jan 8. PMID: 30635236; PMCID: PMC6336113.
• Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner HL, Kuchroo VK, Lanzavecchia A, Notarbartolo S, Sallusto F. Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human T_H17 cells. Nat Immunol. 2019 Jan;20(1):109. doi: 10.1038/s41590-018-0264-2. Erratum for: Nat Immunol. 2018 Oct;19(10):1126-1136. PMID: 30448856.
• Tang R, Rangachari M, Kuchroo VK. Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance. Semin Immunol. 2019 Apr;42:101302. doi: 10.1016/j.smim.2019.101302. PMID: 31604535.
• Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJ. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. doi: 10.1016/j.immuni.2019.09.004. PMID: 31618654; PMCID: PMC6991097.
• Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):709-723.e6. doi: 10.1016/j.immuni.2019.09.005. Epub 2019 Oct 8. PMID: 31604686; PMCID: PMC7076585.
• Delaney C, Schnell A, Cammarata LV, Yao-Smith A, Regev A, Kuchroo VK, Singer M. Combinatorial prediction of marker panels from single-cell transcriptomic data. Mol Syst Biol. 2019 Oct;15(10):e9005. doi: 10.15252/msb.20199005. PMID: 31657111; PMCID: PMC6811728.
• Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT. Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 Oct;20(10):1360-1371. doi: 10.1038/s41590-019-0472-4. Epub 2019 Sep 2. PMID: 31477921; PMCID: PMC6754271.
• Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, Shao F, Krishnamoorthy N, Kuchroo VK, Jones MR, Fine A, Bai Y, Ai X. Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019 Dec 17;51(6):1102-1118.e7. doi: 10.1016/j.immuni.2019.10.002. Epub 2019 Nov 19. PMID: 31757673; PMCID: PMC6937208.
• Schorer M, Kuchroo VK, Joller N. Role of Co-stimulatory Molecules in T Helper Cell Differentiation. Adv Exp Med Biol. 2019;1189:153-177. doi: 10.1007/978-981-32-9717-3_6. PMID: 31758534.
• Sungnak W, Wang C, Kuchroo VK. Multilayer regulation of CD4 T cell subset differentiation in the era of single cell genomics. Adv Immunol. 2019;141:1-31. doi: 10.1016/bs.ai.2018.12.001. Epub 2019 Jan 3. PMID: 30904130.

2018

• Wu C, Chen Z, Xiao S, Thalhamer T, Madi A, Han T, Kuchroo V. SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. Cell Rep. 2018 Jan 16;22(3):653-665. doi: 10.1016/j.celrep.2017.12.068. PMID: 29346764; PMCID: PMC5826610.
• Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. J Immunol. 2018 Apr 15;200(8):3000-3007. doi: 10.4049/jimmunol.1700407. Epub 2018 Mar 2. PMID: 29500245; PMCID: PMC5893394.
• Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 May;24(4):417-426. doi: 10.1038/nm.4501. Epub 2018 Mar 5. Erratum in: Nat Med. 2018 Oct;24(10):1625-1626. PMID: 29505031; PMCID: PMC6263165.
• Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018 Jun;558(7710):454-459. doi: 10.1038/s41586-018-0206-z. Epub 2018 Jun 13. PMID: 29899446; PMCID: PMC6130914.
• Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ. T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation. Cell. 2018 Nov 15;175(5):1307-1320.e22. doi: 10.1016/j.cell.2018.10.008. Epub 2018 Nov 1. PMID: 30392957; PMCID: PMC6239889.
• Dixon KO, Das M, Kuchroo VK. Human disease mutations highlight the inhibitory function of TIM-3. Nat Genet. 2018 Dec;50(12):1640-1641. doi: 10.1038/s41588-018-0289-3. PMID: 30405215; PMCID: PMC6452640.

2017

• A-Gonzalez N, Quintana JA, García-Silva S, Mazariegos M, González de la Aleja A, Nicolás-Ávila JA, Walter W, Adrover JM, Crainiciuc G, Kuchroo VK, Rothlin CV, Peinado H, Castrillo A, Ricote M, Hidalgo A. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med. 2017 May 1;214(5):1281-1296. doi:10.1084/jem.20161375. Epub 2017 Apr 21. PubMed PMID: 28432199; PubMed Central PMCID: PMC5413334.
• Das M, Zhu C, Kuchroo VK. Tim-3 and its role in regulating anti-tumorimmunity. Immunol Rev. 2017 Mar;276(1):97-111. doi: 10.1111/imr.12520. Review.PubMed PMID: 28258697.
• Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK. Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation. Nat Immunol. 2017 Apr;18(4):412-421. doi: 10.1038/ni.3683. Epub 2017 Feb 6. PubMed PMID: 28166218.
• Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, HanT, Oukka M, Kuchroo V. The transcription factor musculin promotes the unidirectional development of peripheral T(reg) cells by suppressing the T(H)2 transcriptional program. Nat Immunol. 2017 Mar;18(3):344-353. doi: 10.1038/ni.3667. Epub 2017 Jan 23. PubMed PMID: 28114290.
• Brauner S, Folkersen L, Kvarnström M, Meisgen S, Petersen S, Franzén-Malmros M, Mofors J, Brokstad KA, Klareskog L, Jonsson R, Westerberg LS, Trollmo C, Malmström V, Ambrosi A, Kuchroo VK, Nordmark G, Wahren-Herlenius M. H1N1 vaccination in Sjögren’s syndrome triggers polyclonal B cell activation and promotes autoantibody production. Ann Rheum Dis. 2017 Oct;76(10):1755-1763. doi: 10.1136/annrheumdis-2016-210509. Epub 2017 Jul 31. PubMed PMID: 28760805; PubMed Central PMCID: PMC5629946.
• Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol. 2017 May 19;2(11). pii: eaaj1738. doi: 10.1126/sciimmunol.aaj1738. PubMed PMID: 28763794; PubMed Central PMCID: PMC5657397.
• Ding Q, Mohib K, Kuchroo VK, Rothstein DM. TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection. J Immunol. 2017 Oct 1;199(7):2585-2595. doi: 10.4049/jimmunol.1602107. Epub 2017 Aug 28. PubMed PMID: 28848066; PubMed Central PMCID: PMC5726915.
• Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. JCI Insight.  2017 Sep 7;2(17). pii: 92321. doi: 10.1172/jci.insight.92321. PubMed PMID: 28878118; PubMed Central PMCID: PMC5621890.
• Joller N, Kuchroo VK. Tim-3, Lag-3, and TIGIT. Curr Top Microbiol Immunol. 2017;410:127-156. doi: 10.1007/82_2017_62. PubMed PMID: 28900677; PubMed Central PMCID: PMC5902028.
• Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 Sep 21;549(7672):351-356.doi: 10.1038/nature24029.Epub 2017 Sep 13. Erratum in: Nature. 2017 Nov 15;:. PubMed PMID: 28902842;PubMed Central PMCID: PMC5746044.
• Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Ternès N, Jegou S, Woods DM, Sodré AL, Hansen M, Meirow Y, Sade-Feldman M, Burra A, Kwek SS, Flament C,Messaoudene M, Duong CPM, Chen L, Kwon BS, Anderson AC, Kuchroo VK, Weide B,Aubin F, Borg C, Dalle S, Beatrix O, Ayyoub M, Balme B, Tomasic G, Di Giacomo AM, Maio M, Schadendorf D, Melero I, Dréno B, Khammari A, Dummer R, Levesque M,Koguchi Y, Fong L, Lotem M, Baniyash M, Schmidt H, Svane IM, Kroemer G,Marabelle A, Michiels S, Cavalcanti A, Smyth MJ, Weber JS, Eggermont AM, Zitvogel L.Predictors of responses to immune checkpoint blockade in advanced melanoma. Nat Commun. 2017 Sep 19;8(1):592. doi: 10.1038/s41467-017-00608-2. PubMed PMID: 28928380; PubMed Central PMCID: PMC5605517.
• Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J,Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JYH, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016 Sep 8;166(6):1500-1511.e9. doi: 10.1016/j.cell.2016.08.052. Erratum in: Cell.2017 Nov 16;171(5):1221-1223. PubMed PMID: 27610572; PubMed Central PMCID:PMC5019125.
• Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL.Transcriptional signature of human pro-inflammatory T(H)17 cells identifiesreduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017 Nov17;8(1):1600. doi: 10.1038/s41467-017-01571-8. PubMed PMID: 29150604; PubMedCentral PMCID: PMC5693957.

2016

• Burkett PR, Kuchroo VK. IL-17 Blockade in Psoriasis. Cell. 2016 Dec 15;167(7):1669. doi: 10.1016/j.cell.2016.11.044. PubMed PMID: 27984714.
• Kishi Y, Kondo T, Xiao S, Yosef N, Gaublomme J, Wu C, Wang C, Chihara N, Regev A, Joller N, Kuchroo VK. Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity. J Exp Med. 2016 Oct 17;213(11):2489-2501. Epub 2016 Sep 26. PubMed PMID: 27670590; PubMed Central PMCID: PMC5068226.
• Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IE. T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia. J Immunol. 2016 Dec 1;197(11):4403-4412. Epub 2016 Oct 24.PubMed PMID: 27798153; PubMed Central PMCID: PMC5123839.
• Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by T(FR) cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3. PubMed PMID:27695002.
• Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JY, Nevin J, Herbst RH, Yanai I,Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016 Sep 8;166(6):1500-1511.e9. doi: 10.1016/j.cell.2016.08.052. PubMed PMID:27610572; PubMed Central PMCID: PMC5019125.
• Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R,Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 Sep 19;213(10):2147-66. doi:10.1084/jem.20150376. Epub 2016 Aug 22. PubMed PMID: 27551155; PubMed Central PMCID: PMC5032726.
• Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK. RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep. 2016 Jul 12;16(2):392-404. doi:10.1016/j.celrep.2016.05.088. Epub 2016 Jun 23. PubMed PMID: 27346359; PubMed Central PMCID: PMC4984261.
• Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601. doi:10.1073/pnas.1600934113. Epub 2016 Jun 16. PubMed PMID: 27313209; PubMed Central PMCID: PMC4941458.
• Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitoryReceptors with Specialized Functions in Immune Regulation. Immunity. 2016 May17;44(5):989-1004. doi: 10.1016/j.immuni.2016.05.001. Review. PubMed PMID:27192565; PubMed Central PMCID: PMC4942846.
• Chihara N, Madi A, Karwacz K, Awasthi A, Kuchroo VK. Differentiation andCharacterization of Tr1 Cells. Curr Protoc Immunol. 2016 Apr1;113:3.27.1-3.27.10. doi: 10.1002/0471142735.im0327s113. PubMed PMID: 27038462.
• Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK,Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. PubMed PMID: 26982724; PubMed Central PMCID: PMC5110397.
• Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC,Kuchroo VK, Behar SM. TIM3 Mediates T Cell Exhaustion during Mycobacteriumtuberculosis Infection. PLoS Pathog. 2016 Mar 11;12(3):e1005490. doi:10.1371/journal.ppat.1005490. eCollection 2016 Mar. PubMed PMID: 26967901; PubMed Central PMCID: PMC4788425.

2015

• Patel DD, Kuchroo VK. Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions. Immunity. 2015 Dec 15;43(6):1040-51. doi:10.1016/j.immuni.2015.12.003. Review. PubMed PMID: 26682981.
• Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1400-12. doi: 10.1016/j.cell.2015.11.009. Epub 2015 Nov 19. PubMed PMID: 26607794; PubMed Central PMCID: PMC4671824.
• Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1413-27. doi: 10.1016/j.cell.2015.10.068. Epub 2015 Nov 19. PubMed: PMID: 26607793; PubMed Central PMCID: PMC4671820.
• Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest. 2015 Nov 2;125(11):4212-22. doi: 10.1172/JCI81151. Epub 2015 Oct 20. PubMed PMID: 26524592; PubMed Central PMCID: PMC4639983.
• Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC,Regev A, Williams MA, Tantin D. Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med. 2015 Nov 16;212(12):2115-31. doi:10.1084/jem.20150363. Epub 2015 Oct 19. PubMed PMID: 26481684; PubMed Central PMCID: PMC4647264.
• Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA,Peterson LB, Bottini N, Wicker LS. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15;195(10):4841-52. doi:10.4049/jimmunol.1402654. Epub 2015 Oct 5. PubMed PMID: 26438525; PubMed Central PMCID: PMC4635565.
• Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015 Nov 2;125(11):4053-62. doi: 10.1172/JCI81187. Epub 2015 Sep 28. PubMed PMID: 26413872; PubMed Central PMCID: PMC4639980.
• Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK. IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Nov 2;125(11):4011-20. doi: 10.1172/JCI75933. Epub 2015 Sep 28. PubMed PMID: 26413871; PubMed Central PMCID: PMC4639966.
• Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C. IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. J Immunol. 2015 Nov 1;195(9):4144-53. doi: 10.4049/jimmunol.1302246. Epub 2015 Sep 25. PubMed PMID:26408664; PubMed Central PMCID: PMC4610870.
• Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14. PubMed PMID: 26371185; PubMed Central PMCID: PMC4577848.
• Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025. PubMed PMID: 26359987; PubMed Central PMCID: PMC4570563.
• Wang C, Collins M, Kuchroo VK. Effector T cell differentiation: are master regulators of effector T cells still the masters? Curr Opin Immunol. 2015 Dec;37:6-10. doi: 10.1016/j.coi.2015.08.001. Epub 2015 Aug 27. Review. PubMed PMID: 26319196.
• Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jul 8;6:7657. doi: 10.1038/ncomms8657. PubMed PMID:26153760.
• Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C,Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron.2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25. PubMed PMID: 26119026; PubMed Central PMCID: PMC4506220.
• Andersson KM, Cavallini NF, Hu D, Brisslert M, Cialic R, Valadi H, Erlandsson MC, Silfverswärd S, Pullerits R, Kuchroo VK, Weiner HL, Bokarewa MI. Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment. Mol Med. 2015 Jun 4;21:536-43. doi:10.2119/molmed.2015.00057. PubMed PMID: 26062018; PubMed Central PMCID:PMC4607618.
• Dardalhon V, Collins M, Kuchroo VK. Physical attraction of Th9 cells is skin deep. Ann Transl Med. 2015 Apr;3(6):74. doi: 10.3978/j.issn.2305-5839.2015.01.28.PubMed PMID: 25992373; PubMed Central PMCID: PMC4416954.
• Burkett PR, Meyer zu Horste G, Kuchroo VK. Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest. 2015 Jun;125(6):2211-9. doi: 10.1172/JCI78085. Epub 2015 May 11. Review. PubMed PMID: 25961452; PubMed Central PMCID: PMC4497747.
• Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015 Apr;125(4):1620-36. doi: 10.1172/JCI75417. Epub 2015 Mar 9. PubMed PMID: 25751064; PubMed Central PMCID: PMC4396492.
• Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK. A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. J Autoimmun. 2015 May;59:38-42. doi: 10.1016/j.jaut.2015.02.001. Epub 2015 Feb 26. PubMed PMID: 25725581; PubMed Central PMCID: PMC4414806.
• Wu C, Chen Z, Kuchroo VK. Ezh2 lines up the chromatin in T regulatory cells. Immunity. 2015 Feb 17;42(2):201-3. doi: 10.1016/j.immuni.2015.01.019. PubMed PMID: 25692693.
• Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM. TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2. PubMed PMID: 25645598;PubMed Central PMCID: PMC4530122.
• Wu C, Chen Z, Kuchroo VK. DUBA-UBR5 axis: other than transactivation. CellRes. 2015 Mar;25(3):273-4. doi: 10.1038/cr.2015.13. Epub 2015 Jan 30. PubMedPMID: 25633593; PubMed Central PMCID: PMC4349248.
• Kuchroo P, Dave V, Vijayan A, Viswanathan C, Ghosh D. Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells Dev. 2015 Feb 15;24(4):437-50.doi: 10.1089/scd.2014.0184. Epub 2014 Nov 3. PubMed PMID: 25229480; PubMedCentral PMCID: PMC4313407.

2014

• Joller N, Kuchroo VK. Good guys gone bad: exTreg cells promote autoimmune arthritis. Nat Med. 2014 Jan; 20(1):15-7. PMID: 24398957.
• Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, Tarhini AA, Tawbi HA, Kirkwood JM, Moschos S, Wang H, Guillaume P, Luescher IF, Krieg A, Anderson AC, Kuchroo VK, Zarour HM. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines. Cancer Res. 2014 Feb 15;74(4):1045-55. PMCID: PMC3952491.
• Vega-Carrascal I, Bergin DA, McElvaney OJ, McCarthy C, Banville N, Pohl K, Hirashima M, Kuchroo VK, Reeves EP, McElvaney NG. Galectin-9 Signaling through TIM-3 Is Involved in Neutrophil-Mediated Gram-Negative Bacterial Killing: An Effect Abrogated within the Cystic Fibrosis Lung. J Immunol. 2014 Mar 1;192(5):2418-31. PMCID: PMC4219323
• Joller N, Lozano E, Burkett PB, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Selective inhibition of proinflammatory Th1 and Th17 but not Th2 responses by TIGIT+ Foxp3+ regulatory T cells. Immunity. 2014.17;40(4):569-81.
• Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Halfer DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small molecule RORgt antagonists inhibit T helper cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89. NIHMSID: 584520
• Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G. TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity. Immunity. 2014 Apr 2. 40(4):542-53.
• Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, KuchrooVK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity. 2014 41(2):270-82. NIHMSID 611280
• Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 2014 May;509(7499):230-4. PMID: 24739967.
• Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17;40(4):569-81. PMID: 24745333.
• da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol Res. 2014 May;2(5):410-22. PMID: 24795354.
• Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest. 2014 Jun 2;124(6):2513-22. PMCID: PMC4089462.
• Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Ging W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB. Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. J Clin Invest. 2014 Aug 1;124(8):3443-54. PMCID: PMC4109530.
• Kuchroo VK, Anderson AC, Freeman GJ. Comment on “Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection.” J Immunol. 2014 Jul 15;193(2):467. PMID: 24994907.
• Kuchroo VK, Anderson AC, Petrovas C. Coinhibitory receptors and CD8 T cell exhaustion in chronic infections. Curr Opi HIV AIDS. 2014 Sep;9(5):439-45. PMID: 25010894.
• Ji H, Liu Y, Zhang Y, Shen XD, Gao F, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury. Hepatology. 2014 Dec;60(6):2052-64. PMID: 25066922.

2013

• Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013 Jan;14(1):72-81.
• Ichinose K, Zhang Z, Koga T, Juan YT, Kis-Tóth K, Sharpe AH, Kuchroo VK, Crispín JC, Tsokos GC. Brief Report: Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar;65(3):764-9. PMCID: PMC3582760
• Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci USA. 2013 Feb 5; 110(6):2270-5. PMCID: PMC3568327
• Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. Induction of pathogenic Th17 cells by inducible salt-sensing kinase SGK1. Nature. 2013 Apr 25;496(7446):513-7. PMCID: PMC3637879
• Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Genert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling Th17 cell differentiation. Nature. 2013 Apr 25;496(7446):461-8. Doi:10.1038/nature 11981. PMCID: 23467089; PMCID: PMC3637864.
• Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ. IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol. 2013 Apr 15;190(8):3977-84.
• Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol. 2013 Apr 15;190(8):4196-204. PMCID: PMC3622150
• Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hor S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakagushi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr;14(4):307-8.
• Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7;110(19): 7802-7. PMCID: PMC3651423
• Sakuishi K, Ngiow SF, Sullivan JM, Teng MW, Kuchroo VK, Smyth MJ, Anderson AC. TIM3+FOXP+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer. Oncoimmunology. 2013 Apr 1;2(4):e23849. PMCID: PMC3654601
• Baeten DL, Kuchroo VK. How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases. Nat Med. 2013 Jul;19(7):824-5.
• Jianjun Yang, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC 3rd, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med. 2013 Jul 1;210(7):1447-62. PMCID: PMC3698516.
• Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013 Sep 3;123(9):4023-35. PMCID: PMC3755983.
• Rangachari M, Kuchroo VK. Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun. 2013 Sep;45-31-9. PMCID: PMC3963137.
• Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. J Immunol. 2013 Oct 1;191(7):3673-80. PMCID: PMC3819731
• Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M. Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors. J Immunol. 2013 Oct 1;191(7):3753-63.
• Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct;14(10):1054-63. PMCID: PMC3964005.

2012

• Ambrosi A, Dzikaite V, Park J, Strandberg L, Kuchroo VK, Herlenius E, Wahren-Herlenius M. Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis. 2012 Mar;71(3):448-54. Epub 2011 Nov 14.
• Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG. Dysregulation of immune homeostasis in autoimmune diseases. Nat Med. 2012 Jan 6; 18(1):42-7.
• Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 1;188(1): 155-62. Epub 2011 Nov 28. PMCID: PMC3245861.
• Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Olive D, Kuchroo V, Zarour HM. CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012 Feb 15;72(4) 887-96. Epub 2011 Dec 28. PMCID: PMC3288235.
• Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 1;188(7):3127-75Feb 17. PMCID: PMC3311782.
• Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B Cells. J Immunol. 2012 Mar 1;188(5)2084-92. Epub 2012 Jan 25. PMCID: PMC3288950.
• Fowler K, Kuchroo VK, Chakraborty A. A model for how signal suration can cetermine distinct outcomes of gene transcription programs. PLoS ONE. 2012;7(3):e33018. Epub 2012 Mar 13. PMCID: PMC3302786.
• Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar K, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes Th17 differentiation by directly silencing Il2 expression. Nat Immuol. 2012 Jul 1;13(8):770-7. PMCID: PMC3541018
• Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robus tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 2012 Jul 8. Doi: 10.1038. PMCID: PMC3518666.
• Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and developoment of systemic autoimmunity in Tim-1 mucin domain-mutant mice. Proc Natl Acad Sci USA. 2012 Jul 24; 109(30):12105-10. PMCID: PMC3409739
• Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host-disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19;120(3):682-90. Epub 2012 Jun 7. PMCID: PMC3401220
• Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunol Rev. 2012 Jul:248(1)122-39.
• Gupta S. Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul 2;122(7):2395-404. PMCID: PMC3386804.
• Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cells function. J Immunol. 2012 Apr 15;188(8):3869-75. Epub 2012 Mar 16. PMCID: PMC3324669
• Lee Y, Awasthi A, Yosef N, Quintana FJ, Peters A, Xiao S, Kleinewietfeld M, Kunder S, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic Th17 cells. Nat Immunol. 2012 Oct; 13(10):991-1. PMCID: PMC3459594
• Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 protects T cell responses by repressing Tim-3-mediated exhasustion and death. Nat Med. 2012 Sep;18(9):1394-400. PMCID: PMC3491118
• Acton SE, Strait JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll M, Kahn ML, Wuchperfennig KW, Turley SJ. Podoplanin-rich stomal networks induce dendritic cell motility via activation of the c-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. Epub 2012 Aug 9. PMCID: PMC3556784
• Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal. 2012 Dec 11;5(254)

2011

• Lazarevic V, Chen X, Shim JH, Swang ES, Jan E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt. Nat immunol. 2011 Jan;12(1): 96-104 PMCID: PMC3077962
• Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting Edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol. 2011 Feb 1;186(3):1338-42. PMCID: PMC3128994
• Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion pehnotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28;117(17):4501-10. PMCID: PMC3099570
• Xiao S, Zhu B, Jin H, Zhu C, Umetsu D, DeKruyff R, Kuchroo VK. Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. Eur J Immunol. 2011 Jun;41(6):1539-49. PMCID: PMC3129006
• Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug;32(8):345-9. Epub 2011 Jun 11. PMCID: PMC3164311.
• Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of Th17 cells occurs in the small intestine. Nature. 2011 Jul 17;475(7357):514-8. PMCID: PMC3148838
• Lee J, Sue EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Phosphotyrosine-dependent coupling of tim-3 to T-cell receptor signaling pathways. Mol Cell Biol. 2011 Oct;31(19):3963-74. Epub 2011 Aug 1. PMCID: PMC3187355
• Thakker P, Marusic S, Stedman NL, Lee KL, McKew JC, Wood A, Goldman S, Leach MW, Collins M, Kuchroo VK, Wolf SF, Clark JD, Hassan-Zahraee M. Cytosolic Phospholipase A₂a blockade abrogates disease during the tissue-damage effector phase of Experimental Autoimmune Encephalomyelitis by its action on APCs. J Immunol. 2011 Aug 15;187(4):1986-97. Not supported by NIH funds
• Peters A, Lee Y, Kuchroo VK. The many faces of Th17 cells. 2011. Curr Opin Immunol. 2011 Dec;23(6):702-6. PMID: 21899997; PMCID: PMC3232281.
• Liu SM, Lee DH, Sullivan JM, Chung D, Jaeger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov 1;121(11):4303-10. PMCID: PMC3204832
• Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Frantz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous tissue inflammation. Immunity. 2011 Dec 23;35(6):986-96. Epub 2011 Dec 15. PMCID: PMC3422678
• Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19001-6. Epub 2011 Nov 3. PMCID: PMC3223445

2010

• Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol. 2010 Feb 15;184(4):1710-20. Epub 2010 Jan 18. PMCID: PMC2829977.
• Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH. Kuchroo VK. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur J Immunol. 2010 Mar;40(3):859-66. PMCID: PMC2837127.
• Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11. PMCID: PMC2889349.
• Kyttaris VC, Zhang Z, Kuchroo VK, Oukka M, Tsokos GC. Cutting Edge: IL-23 Receptor Deficiency Prevents the Development of Lupus Nephritis in C57BL/6-lpr/lpr Mice. J Immunol. 2010 May 1;184(9):4605-9. PMCID: PMC2926666
• Beriou G, Brasdshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1;185(1):46-54. PMCID: PMC2936106
• Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 1;185(3):1383-92. PMCID: PMC2925247
• Mitsdoerffer M, Lee Y, Jäger A, Kim HJ, Korn T, Kolls JK, Cantor H, Bettelli E, Kuchroo VK. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci USA. 2010 Aug 10;107(32):14292-7. Epub 2010 Jul 26. PMCID: PMC2922571
• Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep;11(9):854-61. Epub 2010 Aug 1. PMCID: PMC2940320
• Jin H-T, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed R. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA. 2010 Aug 17;107(33):14733-8. Epub 2010 Aug 2. PMCID: PMC2930455
• Strandberg LS, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, Winqvist O, Olsson T, Wahren-Herlenius M. Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Dtermine Susceptibility in Congenital Heart Block. J Immunol. 2010 Sep 15;185(6):3574-82.
• Zhu C, Anderson AC, Kuchroo VK. TIM-3 and Its Regulatory Role in Immune Responses. Curr Top Microbiol Immunol. 2010 Aug 11. 2011; 350:1-15. Review
• Sakuishi K, Apetoh L, Sullivan JM, Blazer BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010 Sep 27;207(10):2187-94. PMCID: PMC2947065
• Petermann F, Rothhammer V, Claussen MC, Haas JD, Riol-Blanco L, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T. gd T cells ehance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity. 2010 Sep 24; 33:351-363. PMCID: PMC3008772
• Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V and Zarour HM. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction melanoma patients. J Exp Med. 2010 Sep 27;207(10):215-86. PMCID: PMC2947081
• Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med. 2010 Oct 25;207(11):2343-54. PMCID: PMC2964580

2009

• Oke V, Vassilaki I, Espinosa A, Strandberg L, Kuchroo VK, Nyberg F, Wahren-Herlenius M. High Ro52 expression in spontaneous and UV-induced cutaneous inflammation. J Invest Dermatol. 2009. Aug;129(8):2000-10. Epub 2009 Feb 5.
• Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB. Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol. 2009. Feb 1;182(3):1379-85.
• Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17 producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30;113(18):4240-9. PMCID: PMC2676084
• Awasthi A, Riol-Blanco L, Jaeger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting Edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J Immunol. 2009 May 15; 182(10):5904-8. PMCID: PMC2702203
• Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci USA. 2009. Aug 4;106(31):12885-90. PMCID: PMC2722314
• Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting Edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009 Jul 15; 183(2):797-801. Epub 2009 Jul. PMCID: PMC2768608
• Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta M, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by dysregulating the IL-23-Th17 pathway. J Exp Med. 2009 Aug 3;206(8):1661-71. Epub 2009 Jul 27. PMCID: PMC2722164
• Hastings W, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep;39(9): 2492-501. PMCID: PMC2759376
• Araki M, Chung D, Liu S, Rainbow D, Chamberlain G, Garner V, Hunter K MD, Vijayakrishnan L, Peterson L, Oukka M, Sharpe A, Sobel R, Kuchroo VK and Wicker L. Genetic evidence that the differential expression of the ligand- independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol. 2009 Oct 15;183(8): 5146-57. PMCID: PMC2871291
• Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance and function of induced regulatory T cells. J Exp Med. 2009 Dec 21;206(13):3015-29. PMCID: PMC2806460
• Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009 Dec1;183(11):7169-77. PMCID: PMC2921715
• Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Negative immune regulator Tim-3 is over-expressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol 2009;83:9122-30. PMCID: PMC2738247

2008

• Strandberg L, Ambrosi A, Espinosa A, Ottosson L, Eloranta ML, Zhou W, Elfving A, Greenfield E, Kuchroo VK, Wahren-Herlenius M. Interferon-alpha Induces Up-regulation and Nuclear Translocation of the Ro52 Autoantigen as Detected by a Panel of Novel Ro52-specific Monoclonal Antibodies. J Clin Immunol. 2008; 28:220-31
• Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest. 2008 Feb; 118(2): 735-41. PMCID: PMC2129234
• Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M. Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol. 2008 Apr;127(1):78-88.
• Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V. , Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 Expressed on APCs Induces T Cell Expansion and Survival. J Immunol. 2008 Apr 1;180(7):4706-4713. Accepted for publication Jan 2008. PMCID: PMC2948965
• Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol. 2008 May 15;180(10):6970-6. Accepted for publication Mar 2008.
• Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF{beta}-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis. J Immunol. 2008 Jun 1;180(11):7327-37. Accepted for publication Mar 2008.
• Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008 Jul 17; 454:350-2. PMCID: PMC2760130
• Elyaman W, Kivisäkk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol. 2008 Aug; 173(2): 411-22. PMCID: PMC2475778
• Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc Natl Acad Sci USA. 2008 Aug 5; 105(31): 10865-70. PMCID: PMC2504840
• Xiao S, Jin H, Korn T, Kiu SM, Oukka M, Lim B, Kuchroo VK. Retinoic acid increases Fox-3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol. 2008 Aug 15; 181(4): 2277-84. PMCID: PMC2722959
• Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho I-C, Khoury S, Oukka M, Kuchroo VK. IL-4 inhibits TGF-b-induced-Foxp3⁺ T cells and generates a Foxp3^– effector T cells. Nat Immunol. 2008. Dec; 9(12): 1347-55. PMCID: PMC2999006
• Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, Kuchroo VK, Oukka M. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci USA. 2008 Nov 25;105(47): 18460-5. PMCID: PMC2587589
• Dardalhon V, Korn T, Kuchroo VK, Anderson AC. Role of Th1 and Th17 cells in organs-specific autoimmunity. J Autoimmun. 2008 Nov; 31(3): 252-6. PMCID: PMC3178062
• Anderson AC, Chandwaskar R, Lee DH, Kuchroo VK. Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC. J Immunol 2008 Dec 1;181(11): 7449-52. PMCID: PMC2614216
• Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, Watanabe K, Niki T, Katoh S, Miyake M, Nagahata S, Hirabayashi J, Kuchroo VK, Yamauchi A, Hirashima M. Galetctin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J Immunol 2008 Dec 1; 181(11): 7660-9.
• Hafler JP, Maier LM, Copper JD, Plagnol V, Hinks A, Simmonds MJ, Stevens HE, Walker NM, Healy B, Howson JM, Maisuria M, Duley S, Coleman G, Gough SC, The International Multiple Sclerosis Genetics Consortium (IMSGC), Worthington J, Kuchroo VK, Wicker LS, Todd JA. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 2009 Jan; 10(1):5-10. Epub 2008 Oct 30. PMCID: PMC2635550
• Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho I-C, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells TH17 cells. Nat Immunol. 2009 Feb;10(2):167-75. Epub 2008 Dec 21. PMCID: PMC2742982

2007

• Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol. 2007 Jan 1;178(1):179-85.
• Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J Immunol. 2007 Jan 1;178(1):172-8.
• O’Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb;13(2):211-7. Epub 2007 Jan 12.
• Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med. 2007 Feb 19;204(2):285-97. Epub 2007 Feb 5.
• Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Backstrom BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007 Apr;13(4):423-31. Epub 2007 Mar 25.
• Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11;204(6):1257-65. Epub 2007 May 14. PMCID: PMC2118603
• Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A, Kuchroo VK, Rajewsky K, Schmidt-Supprian M. I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2007 Jul 1;179(1):179-85.
• Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant. 2007 Jul;7(7):1722-32. Epub 2007 May 19.
• Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 9;204(7):1691-702. Epub 2007 Jul 2. PMCID: PMC2118637
• Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation. 2007 Jul 15;84(1 Suppl):S12-6.
• Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007 Jul 26;448(7152):484-7. Epub 2007 Jun 20.
• Illes Z, Waldner H, Reddy J, Anderson AC, Sobel RA, Kuchroo VK. Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background. Int Immunol. 2007 Oct;19(10):1235-48.
• Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ. CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis. J Immunol. 2007 Oct 15;179(8):5228-5237.
• Anderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science. 2007 Nov 16;318(5853):1141-3.
• Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007; 8(12):1380-9.
• Seki M, Sakata KM, Oomizu S, Arikawa T, Sakata A, Ueno M, Nobumoto A, Niki T, Saita N, Ito K, Dai SY, Katoh S, Nishi N, Tsukano M, Ishikawa K, Yamauchi A, Kuchroo V, Hirashima M. Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts. Arthritis Rheum. 2007 Dec;56(12):3968-76.

2006

• Greenfield EA, Reddy J, Lees A, Dyer CA, Koul O, Nguyen K, Bell S, Kassam N, Hinojoza J, Eaton MJ, Lees MB, Kuchroo VK, Sobel RA. Monoclonal antibodies to distinct regions of human myelin proteolipid protein simultaneously recognize central nervous system myelin and neurons of many vertebrate species. J Neurosci Res. 2006 Feb 15;83(3):415-31.
• Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, Weiner HL. Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol. 2006 Apr;18(4):495-503. Epub 2006 Mar 15.
  Waldner H, Sobel RA, Price N, Kuchroo VK. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol. 2006 May 1;176(9):5455-62.
• Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8. Epub 2006 Apr 30.
• Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M. The Sjogren’s syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006 May 15;176(10):6277-85.
• Koguchi K, Anderson DE, Yang L, O’Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006 Jun 12;203(6):1413-8. Epub 2006 Jun 5. PMCID: PMC2118310
• Bettelli E, Baeten D, Jager A, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006 Sep;116(9):2393-402. PMCID: PMC1555670

2005

• Salomonsson S, Sonesson SE, Ottosson L, Muhallab S, Olsson T, Sunnerhagen M, Kuchroo VK, Thoren P, Herlenius E, Wahren-Herlenius M. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. J Exp Med. 2005 Jan 3;201(1):11-7. PMCID: PMC2212767
• Bettelli E, Kuchroo VK. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J Exp Med. 2005 Jan 17;201(2):169-71. PMCID: PMC2212800
• Stern JN, Illes Z, Reddy J, Keskin DB, Fridkis-Hareli M, Kuchroo VK, Strominger JL. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1620-5. Epub 2005 Jan 21. PMCID: PMC547868
• Ottosson L, Salomonsson S, Hennig J, Sonesson SE, Dorner T, Raats J, Kuchroo VK, Sunnerhagen M, Wahren-Herlenius M. Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein. Scand J Immunol. 2005 Feb;61(2):109-18.
• Ellmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. J Immunol. 2005 Feb 15;174(4):1938-46.
• Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol. 2005 May;6(5):455-64. Epub 2005 Mar 27.
• Yu P, Gregg RK, Bell JJ, Ellis JS, Divekar R, Lee HH, Jain R, Waldner H, Hardaway JC, Collins M, Kuchroo VK, Zaghouani H. Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigen. J Immunol. 2005 Jun 1;174(11):6772-80.
• Illes Z, Waldner H, Reddy J, Bettelli E, Nicholson LB, Kuchroo VK. T cell tolerance induced by cross-reactive TCR ligands can be broken by superagonist resulting in anti-inflammatory T cell cytokine production. J Immunol. 2005 Aug 1;175(3):1491-7.
• Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol. 2005 Aug 1;175(3):1558-65.
• Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005 Aug 1;202(3):437-44. Epub 2005 Jul 25. Erratum in: J Exp Med. 2005 Sep 19;202(6):877. PMCID: PMC2213076
• Hennig J, Ottosson L, Andresen C, Horvath L, Kuchroo VK, Broo K, Wahren-Herlenius M, Sunnerhagen M. Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52. J Biol Chem. 2005 Sep 30;280(39):33250-61. Epub 2005 Jun 17.
• Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 1;175(9):5591-5.
• Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005 Dec;6(12):1245-52. Epub 2005 Nov 13.
• Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol. 2005 Dec 1;175(11):7341-7.
• Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, Santambrogio L, Kuchroo VK, Strominger JL. Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005 Dec;35(12):3683-93.

1978-2004

• Kuchroo VK, Gupta RKP, Kalra DS. Horn cancer transplantation in hamster cheek pouch. Haryana Vet. 1978; 17:125-6.
• Kuchroo VK, Gupta RKP, Kalra DS. A note on antigenic relationship between normal bovine skin and horn cancer tissue. Ind J Anim Sci. 1979; 49:667-78.
• Kuchroo V, Gupta RK, Kalra DS. Antigenic similarity between squamous cell carcinoma of horn (horn cancer) and normal bovine fetal tissues. Trop Anim Health Prod. 1979 Nov;11(4):203-7.
• Gupta RK, Sadana JR, Kuchroo VK, Kalra DS. Horn cancer in an intact bull. Vet Rec. 1980 Sep 27;107(13):312.
• Kuchroo VK, Gupta RKP, Sadana JR, Kalra DS. A preliminary study on rosette forming lymphocyte count in animals affected with squamous cell carcinoma of horn, prior to and after treatment. Indian Vet Med J. 1980; 4:183-94.
• Kuchroo V, Gupta RK, Kalra DS. Thymus derived rosette forming cell counts and lymphocyte response to phytohaemagglutinin in animals affected with squamous cell carcinoma of horn. Res Vet Sci. 1981 Sep;31(2):144-6.
• Kuchroo VK, Dutta BM, Gupta RK. Tumour associated antigens in bovine horn cancer. Aust Vet J. 1982 Jan;58(1):16-9.
• Kuchroo VK, Jennings PA. Rosetting of bovine T-lymphocytes with autologous and allogeneic red blood cells. Vet Immunol Immunopathol. 1982 Sep;3(5):461-74.
• Kuchroo VK, Jennings PA, Spradbrow PB. Bovine ocular squamous cell carcinoma: tumor-associated immunity detected by E-rosette augmentation test. J Natl Cancer Inst. 1983 Feb;70(2):305-9.
• Kuchroo VK, Halliday WJ, Jennings PA, Spradbrow PB. Serum blocking factors in bovine ocular squamous cell carcinoma demonstrated by inhibition of erythrocyte rosette augmentation. Cancer Res. 1983 Mar;43(3):1325-9.
• Kuchroo VK, Spradbrow PB. Tumour-associated antigens in bovine ocular squamous cell carcinoma: studies with sera from tumour-bearing animals.Vet Immunol Immunopathol. 1985 May;9(1):23-36.
• Nelson M, Nelson DS, Spradbrow PB, Kuchroo VK, Jennings PA, Cianciolo GJ, Snyderman R. Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. Clin Exp Immunol. 1985 Jul;61(1):109-17.
• Lee VK, Harriott TG, Kuchroo VK, Halliday WJ, Hellström I, Hellström KE. Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6286-90.
• Kuchroo VK, Halliday WJ. Cellular requirements for the suppression of leucocyte adherence inhibition reactions by serum factors from tumour-bearing mice. Immunology. 1986 Apr; 57(4): 545-52.
• Kuchroo VK, Lee VK, Hellström I, Hellström KE, Halliday WJ. Tumor-specific idiotopes on suppressor factors and suppressor cells revealed by monoclonal anti-idiotope antibodies. Cell Immunol. 1987 Jan;104(1):105-14.
• Nelson M, Nelson DS, Kuchroo VK, Spradbrow PB, Jennings PA. Depression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma. Cancer Immunol Immunother. 1987;24(3):231-6.
• Steele JK, Kawasaki H, Kuchroo VK, Minami M, Levy JG, Dorf ME. A monoclonal antibody raised to tumor-specific T cell-derived suppressor factors also recognizes T suppressor inducer factors of the 4-hydroxy-3-nitrophenyl acetyl hapten suppressor network. J Immunol. 1987 Oct 15;139(8):2629-34.
• Jaureguiberry B, Liao L, Kuchroo V, Dorf ME, Diamond B. Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. J Immunol. 1988 May 15;140(10):3286-9. Erratum in: J Immunol 1990 Oct 15;145(8):2773.
• Kuchroo VK, Minami M, Diamond B, Dorf ME. Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression. J Immunol. 1988 Jul 1;141(1):10-6.
• Kuchroo VK, Noma T, Minami M, Dorf ME.Down-regulation of suppressor cell induction. Immunology. 1988 Aug;64(4):633-42.
• Kuchroo VK, Steele JK, Billings PR, Selvaraj P, Dorf ME. Expression of CD3-associated antigen-binding receptors on suppressor T cells. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9209-13.
• Steele JK, Kuchroo VK, Kawasaki H, Jayaraman S, Iwata M, Ishizaka K, Dorf ME. A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks. J Immunol. 1989 Apr 1;142(7):2213-20.
• Kuchroo VK, Minami M, Diamond B, Dorf ME. Requirements for suppressor cell activation. Role of accessory cells. J Immunol. 1989 Apr 1;142(7):2192-9.
• Ishikura H, Jayaraman S, Kuchroo V, Diamond B, Saito S, Dorf ME. Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity. J Immunol. 1989 Jul 15;143(2):414-9.
• Kuchroo VK, Steele JK, O’Hara RM Jr, Jayaraman S, Selvaraj P, Greenfield E, Kubo RT, Dorf ME. Relationships between antigen-specific helper and inducer suppressor T cell hybridomas. J Immunol. 1990 Jul 15;145(2):438-48.
• Kuchroo VK, Billings PR, Levine C, Martin CA, Kubo RT, Dorf ME. Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex. J Immunol. 1990 Aug 15;145(4):1059-65.
• Wilson SD, Kuchroo VK, Israel DI, Dorf ME. Expression and characterization of TCA3: a murine inflammatory protein. J Immunol. 1990 Oct 15;145(8):2745-50.
• Collins M, Kuchroo VK, Whitters MJ, O’Hara RM Jr, Kelleher K, Kubo RT, Dorf ME. Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function. J Immunol. 1990 Nov 1;145(9):2809-19.
• Gallina MJ, Kuchroo VK, Steele JK. Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium. J Immunol. 1990 Dec 1;145(11):3570-7
• Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12.
• Kuchroo VK, Byrne MC, Atsumi Y, Greenfield E, Connolly JB, Whitters MJ, O’Hara RM Jr, Collins M, Dorf ME. T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8700-4.
• Kuchroo VK, Sobel RA, Laning JC, Martin CA, Greenfield E, Dorf ME, Lees MB. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage. J Immunol. 1992 Jun 15;148(12):3776-82.
• Greer JM, Kuchroo VK, Sobel RA, Lees MB. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol. 1992 Aug 1;149(3):783-8.
• Sobel RA, Kuchroo VK. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J Immunol. 1992 Aug 15;149(4):1444-51.
• Ozdemirli M, el-Khatib M, Bastiani L, Akdeniz H, Kuchroo V, Ju ST. The cytotoxic process of CD4 Th1 clones. J Immunol. 1992 Sep 15;149(6):1889-95.
• Byrne MC, O’Hara RM Jr, Kuchroo VK, Jayaraman S, Rao A, Dorf ME, Collins M. The role of the T cell receptor alpha chain in antigen-specific immune suppression. Ann N Y Acad Sci. 1993 Jun 23;685:611-3.
• Kuchroo VK, Martin CA, Greer JM, Ju ST, Sobel RA, Dorf ME. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol. 1993 Oct 15;151(8):4371-82.
• Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK. ’Lupus-prone’ mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. Pathobiology. 1994;62(3):113-9.
• Franco A, Southwood S, Arrhenius T, Kuchroo VK, Grey HM, Sette A, Ishioka GY. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur J Immunol. 1994 Apr;24(4):940-6.
• Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 1;179(5):1659-64.
• Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26;265(5176):1237-40.
• Kuchroo VK, Greer JM, Kaul D, Ishioka G, Franco A, Sette A, Sobel RA, Lees MB. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J Immunol. 1994 Oct 1;153(7):3326-36.
• Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol. 1995 Jan;25(1):207-11.
• O’Hara RM Jr, Byrne MC, Kuchroo VK, Nagelin A, Whitters MJ, Jayaraman S, Henderson SL, Dorf ME, Collins M. T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction. J Immunol. 1995 Mar 1;154(5):2075-81.
• Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995 Mar 10;80(5):707-18.
• Kuchroo VK, Byrne MC, Greenfield E, Whitters MJ, Nalefsky EA, Rao A, Collins M, Dorf ME. Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity. J Immunol. 1995 May 15;154(10):5030-8.
• Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995 Jul 13;376(6536):177-80. Erratum in: Nature 1995 Sep 21;377(6546):257.
• Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK, Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol. 1995 Jul 15;155(2):982-92.
• Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 1995 Oct;3(4):397-405.
• Greer JM, Sobel RA, Sette A, Southwood S, Lees MB, Kuchroo VK. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. J Immunol. 1996 Jan 1;156(1):371-9.
• Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA Jr, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):388-91.
• Encinas JA, Lees MB, Sobel RA, Symonowicz C, Greer JM, Shovlin CL, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol. 1996 Sep 1;157(5):2186-92.
• Ranger AM, Das MP, Kuchroo VK, Glimcher LH. B7-2 (CD86) is essential for the development of IL-4-producing T cells. Int Immunol. 1996 Oct;8(10):1549-60.
• Das MR, Cohen A, Zamvil SS, Offner H, Kuchroo VK. Prior exposure to superantigen can inhibit or exacerbate autoimmune encephalomyelitis: T-cell repertoire engaged by the autoantigen determines clinical outcome. J Neuroimmunol. 1996 Dec;71(1-2):3-10.
• Ausubel LJ, Kwan CK, Sette A, Kuchroo V, Hafler DA. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15317-22.
• Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Hollsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol. 1997 Mar 1;158(5):2025-34.
• Nicholson LB, Murtaza A, Hafler BP, Sette A, Kuchroo VK. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. PMCID: PMC23155
• Das MP, Nicholson LB, Greer JM, Kuchroo VK. Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. J Exp Med. 1997 Sep 15;186(6):867-76. PMCID: PMC2199041
• Waldner H, Sobel RA, Howard E, Kuchroo VK. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J Immunol. 1997 Oct 1;159(7):3100-3.
• Hollsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15;159(10):4799-805.
• Nicholson LB, Waldner H, Carrizosa AM, Sette A, Collins M, Kuchroo VK. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):264-9. PMCID: PMC18196
• Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol. 1998 Oct 1;161(7):3299-306.
• Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol. 1998 Oct 1;161(7):3307-14.
• Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet. 1999 Feb;21(2):158-60.
• Murtaza A, Kuchroo VK, Freeman GJ. Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. Int Immunol. 1999 Mar;11(3):407-16.
• Stremmel C, Greenfield EA, Howard E, Freeman GJ, Kuchroo VK. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. J Exp Med. 1999 Mar 15;189(6):919-30.
• Liu L, Kuchroo VK, Weiner HL. B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J Immunol. 1999 Aug 15;163(4):2284-90.
• Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int Immunol. 1999 Sep;11(9):1573-80.
• Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med. 1999 Sep 6;190(5):733-40. PMCID: PMC2195617
• Nicholson LB, Anderson AC, Kuchroo VK. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands. Int Immunol. 2000 Feb;12(2):205-13.
• Anderson AC, Nicholson LB, Legge KL, Turchin V, Zaghouani H, Kuchroo VK. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med. 2000 Mar 6;191(5):761-70. PMCID: PMC2195861
• Waldner H, Whitters MJ, Sobel RA, Collins M, Kuchroo VK. Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3412-7. PMCID: PMC16253
• Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M. IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J Immunol. 2000 Apr 1;164(7):3563-72.
• Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol. 2000 Jun 15;202(2):88-96.
• Nicholson LB, Kuchroo VK. Selecting killers: the line between life and death. Nat Immunol. 2000 Sep;1(3):192-4.
• McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 1;165(9):5035-40.
• Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells. J Immunol. 2000 Dec 1;165(11):6091-8.
• Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar;13(3):257-64.
• Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SD. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Apr;107(8):995-1006. PMCID: PMC199558
• Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci. 2001 Jun 1;21(11):3740-8. Erratum in: J Neurosci 2001 Aug 1;21(15):1a.
• Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VK. Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. Eur J Immunol. 2001 Sep;31(9):2818-28.
• Gaglia JL, Mattoo A, Greenfield EA, Freeman GJ, Kuchroo VK. Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation. Cell Immunol. 2001 Nov 1;213(2):83-93.
• McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16.
• Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31;415(6871):536-41.
• Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol. 2002 May 15;168(10):5070-8.
• Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLs need defenses against the tumor. Nat Med. 2002 Aug;8(8):787-9
• Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol. 2002 Sep;32(9):2687-97.
• Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. 2002 Oct 15;100(8):2899-907.
• Munder M, Bettelli E, Monney L, Slavik JM, Nicholson LB, Kuchroo VK. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med. 2002 Nov 4;196(9):1151-62. PMCID: PMC2194103
• Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15;169(10):5382-6.
• Wahren-Herlenius M, Kuchroo VK. Killers come to the rescue. Nat Biotechnol. 2002 Dec; 20(12): 1205-6
• Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003 Jan 15;170(2):870-7.
• Kuchroo VK, Nicholson LB. Immunology: Fast and feel good? Nature. 2003 Mar 6;422(6927):27-8.
• Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81. PMCID: PMC2193967
• Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003 Jul;33(7):2022-2032.
• Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003 Sep;21(9):1033-9. Epub 2003 Aug 10.
• Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov;4(11):1102-10. Epub 2003 Oct 12.
• Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutierrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov;4(11):1093-101. Epub 2003 Oct 12.
• Anderson AC, Kuchroo VK. Expression of self-antigen in the thymus: a little goes a long way. J Exp Med. 2003 Dec 1;198(11):1627-9. PMCID: PMC2194139
• Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Backstrom BT. Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004 Jan;34(1):165-73.
• Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb;16(2):249-56.
• Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest. 2004 Apr;113(7):990-7. PMCID: PMC379316
• Vijayakrishnan L, Slavik JM, Illes Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 2004 May;20(5):563-75.
• Khademi M, Illes Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallstrom E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol. 2004 Jun 1;172(11):7169-76.
• Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity. 2004 Jun;20(6):695-705.
• Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol. 2004 Jul 1;173(1):157-63.
• Petersen TR, Gulland S, Bettelli E, Kuchroo V, Palmer E, Backstrom BT. A chimeric T cell receptor with super-signaling properties. Int Immunol. 2004 Jul;16(7):889-94. Epub 2004 May 17.
• Greve B, Reddy J, Waldner HP, Sobel RA, Kuchroo VK. Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes. Eur J Immunol. 2004 Jul;34(7):1828-38.
• Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 2004 Jul;34(7):1839-48.
• Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004 Jul 5;200(1):79-87. PMCID: PMC2213316
• Anderson AC, Reddy J, Nazareno R, Sobel RA, Nicholson LB, Kuchroo VK. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol. 2004 Jul 15;173(2):828-34.
• Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6. PMCID: PMC489996
• Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 1;173(3):1689-98.
• Stern JN, Illes Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11743-8.  PMCID: PMC511046
• Illes Z, Stern JN, Reddy J, Waldner H, Mycko MP, Brosnan CF, Ellmerich S, Altmann DM, Santambrogio L, Strominger JL, Kuchroo VK. Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11749-54. PMCID: PMC511047
• Tadokoro CE, Vallochi AL, Rios LS, Martins GA, Schlesinger D, Mosca T, Kuchroo VK, Rizzo LV, Abrahamsohn IA. Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosomacruzi. J Autoimmun. 2004 Sep;23(2):103-15. PMID: 15324929.
• Reddy J, Illes Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK. Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15434-9. PMCID: PMC524444