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2015

Patel DD, Kuchroo VK. Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions. Immunity. 2015 Dec 15;43(6):1040-51. doi:10.1016/j.immuni.2015.12.003. Review. PubMed PMID: 26682981.

Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1400-12. doi: 10.1016/j.cell.2015.11.009. Epub 2015 Nov 19. PubMed PMID: 26607794; PubMed Central PMCID: PMC4671824.

Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. 2015 Dec 3;163(6):1413-27. doi: 10.1016/j.cell.2015.10.068. Epub 2015 Nov 19. PubMed: PMID: 26607793; PubMed Central PMCID: PMC4671820.

Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest. 2015 Nov 2;125(11):4212-22. doi: 10.1172/JCI81151. Epub 2015 Oct 20. PubMed PMID: 26524592; PubMed Central PMCID: PMC4639983.

Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC,Regev A, Williams MA, Tantin D. Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med. 2015 Nov 16;212(12):2115-31. doi:10.1084/jem.20150363. Epub 2015 Oct 19. PubMed PMID: 26481684; PubMed Central PMCID: PMC4647264.

Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA,Peterson LB, Bottini N, Wicker LS. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15;195(10):4841-52. doi:10.4049/jimmunol.1402654. Epub 2015 Oct 5. PubMed PMID: 26438525; PubMed Central PMCID: PMC4635565.

Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015 Nov 2;125(11):4053-62. doi: 10.1172/JCI81187. Epub 2015 Sep 28. PubMed PMID: 26413872; PubMed Central PMCID: PMC4639980.

Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK. IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Nov 2;125(11):4011-20. doi: 10.1172/JCI75933. Epub 2015 Sep 28. PubMed PMID: 26413871; PubMed Central PMCID: PMC4639966.

Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C. IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. J Immunol. 2015 Nov 1;195(9):4144-53. doi: 10.4049/jimmunol.1302246. Epub 2015 Sep 25. PubMed PMID:26408664; PubMed Central PMCID: PMC4610870.

Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14. PubMed PMID: 26371185; PubMed Central PMCID: PMC4577848.

Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10;162(6):1338-52. doi: 10.1016/j.cell.2015.08.025. PubMed PMID: 26359987; PubMed Central PMCID: PMC4570563.

Wang C, Collins M, Kuchroo VK. Effector T cell differentiation: are master regulators of effector T cells still the masters? Curr Opin Immunol. 2015 Dec;37:6-10. doi: 10.1016/j.coi.2015.08.001. Epub 2015 Aug 27. Review. PubMed PMID: 26319196.

Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jul 8;6:7657. doi: 10.1038/ncomms8657. PubMed PMID:26153760.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C,Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron.2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25. PubMed PMID: 26119026; PubMed Central PMCID: PMC4506220.

Andersson KM, Cavallini NF, Hu D, Brisslert M, Cialic R, Valadi H, Erlandsson MC, Silfverswärd S, Pullerits R, Kuchroo VK, Weiner HL, Bokarewa MI. Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment. Mol Med. 2015 Jun 4;21:536-43. doi:10.2119/molmed.2015.00057. PubMed PMID: 26062018; PubMed Central PMCID:PMC4607618.

Dardalhon V, Collins M, Kuchroo VK. Physical attraction of Th9 cells is skin deep. Ann Transl Med. 2015 Apr;3(6):74. doi: 10.3978/j.issn.2305-5839.2015.01.28.PubMed PMID: 25992373; PubMed Central PMCID: PMC4416954.

Burkett PR, Meyer zu Horste G, Kuchroo VK. Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest. 2015 Jun;125(6):2211-9. doi: 10.1172/JCI78085. Epub 2015 May 11. Review. PubMed PMID: 25961452; PubMed Central PMCID: PMC4497747.

Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015 Apr;125(4):1620-36. doi: 10.1172/JCI75417. Epub 2015 Mar 9. PubMed PMID: 25751064; PubMed Central PMCID: PMC4396492.

Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK. A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. J Autoimmun. 2015 May;59:38-42. doi: 10.1016/j.jaut.2015.02.001. Epub 2015 Feb 26. PubMed PMID: 25725581; PubMed Central PMCID: PMC4414806.

Wu C, Chen Z, Kuchroo VK. Ezh2 lines up the chromatin in T regulatory cells. Immunity. 2015 Feb 17;42(2):201-3. doi: 10.1016/j.immuni.2015.01.019. PubMed PMID: 25692693.

Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM. TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2. PubMed PMID: 25645598;PubMed Central PMCID: PMC4530122.

Wu C, Chen Z, Kuchroo VK. DUBA-UBR5 axis: other than transactivation. CellRes. 2015 Mar;25(3):273-4. doi: 10.1038/cr.2015.13. Epub 2015 Jan 30. PubMedPMID: 25633593; PubMed Central PMCID: PMC4349248.

Kuchroo P, Dave V, Vijayan A, Viswanathan C, Ghosh D. Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells Dev. 2015 Feb 15;24(4):437-50.doi: 10.1089/scd.2014.0184. Epub 2014 Nov 3. PubMed PMID: 25229480; PubMedCentral PMCID: PMC4313407.

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