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2012

Ambrosi A, Dzikaite V, Park J, Strandberg L, Kuchroo VK, Herlenius E, Wahren-Herlenius M. Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis. 2012 Mar;71(3):448-54. Epub 2011 Nov 14.

Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG. Dysregulation of immune homeostasis in autoimmune diseases. Nat Med. 2012 Jan 6; 18(1):42-7.

Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 1;188(1): 155-62. Epub 2011 Nov 28. PMCID: PMC3245861.

Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Olive D, Kuchroo V, Zarour HM. CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012 Feb 15;72(4) 887-96. Epub 2011 Dec 28. PMCID: PMC3288235.

Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 1;188(7):3127-75Feb 17. PMCID: PMC3311782.

Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B Cells. J Immunol. 2012 Mar 1;188(5)2084-92. Epub 2012 Jan 25. PMCID: PMC3288950.

Fowler K, Kuchroo VK, Chakraborty A. A model for how signal suration can cetermine distinct outcomes of gene transcription programs. PLoS ONE. 2012;7(3):e33018. Epub 2012 Mar 13. PMCID: PMC3302786.

Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar K, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes Th17 differentiation by directly silencing Il2 expression. Nat Immuol. 2012 Jul 1;13(8):770-7. PMCID: PMC3541018

Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robus tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 2012 Jul 8. Doi: 10.1038. PMCID: PMC3518666.

Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and developoment of systemic autoimmunity in Tim-1 mucin domain-mutant mice. Proc Natl Acad Sci USA. 2012 Jul 24; 109(30):12105-10. PMCID: PMC3409739

Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host-disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19;120(3):682-90. Epub 2012 Jun 7. PMCID: PMC3401220

Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunol Rev. 2012 Jul:248(1)122-39.

Gupta S. Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul 2;122(7):2395-404. PMCID: PMC3386804.

Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 axis regulates human T cells function. J Immunol. 2012 Apr 15;188(8):3869-75. Epub 2012 Mar 16. PMCID: PMC3324669

Lee Y, Awasthi A, Yosef N, Quintana FJ, Peters A, Xiao S, Kleinewietfeld M, Kunder S, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic Th17 cells. Nat Immunol. 2012 Oct; 13(10):991-1. PMCID: PMC3459594

Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 protects T cell responses by repressing Tim-3-mediated exhasustion and death. Nat Med. 2012 Sep;18(9):1394-400. PMCID: PMC3491118

Acton SE, Strait JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll M, Kahn ML, Wuchperfennig KW, Turley SJ. Podoplanin-rich stomal networks induce dendritic cell motility via activation of the c-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. Epub 2012 Aug 9. PMCID: PMC3556784

Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal. 2012 Dec 11;5(254)

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