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2011

Lazarevic V, Chen X, Shim JH, Swang ES, Jan E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt. Nat immunol. 2011 Jan;12(1): 96-104 PMCID: PMC3077962

Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting Edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol. 2011 Feb 1;186(3):1338-42. PMCID: PMC3128994

Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion pehnotype in mice with disseminated acute myelogenous leukemia. Blood. 2011 Apr 28;117(17):4501-10. PMCID: PMC3099570

Xiao S, Zhu B, Jin H, Zhu C, Umetsu D, DeKruyff R, Kuchroo VK. Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. Eur J Immunol. 2011 Jun;41(6):1539-49. PMCID: PMC3129006

Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 2011 Aug;32(8):345-9. Epub 2011 Jun 11. PMCID: PMC3164311.

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O’Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of Th17 cells occurs in the small intestine. Nature. 2011 Jul 17;475(7357):514-8. PMCID: PMC3148838

Lee J, Sue EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Phosphotyrosine-dependent coupling of tim-3 to T-cell receptor signaling pathways. Mol Cell Biol. 2011 Oct;31(19):3963-74. Epub 2011 Aug 1. PMCID: PMC3187355

Thakker P, Marusic S, Stedman NL, Lee KL, McKew JC, Wood A, Goldman S, Leach MW, Collins M, Kuchroo VK, Wolf SF, Clark JD, Hassan-Zahraee M. Cytosolic Phospholipase A2a blockade abrogates disease during the tissue-damage effector phase of Experimental Autoimmune Encephalomyelitis by its action on APCs. J Immunol. 2011 Aug 15;187(4):1986-97. Not supported by NIH funds

Peters A, Lee Y, Kuchroo VK. The many faces of Th17 cells. 2011. Curr Opin Immunol. 2011 Dec;23(6):702-6. Epub ahead of print 2011 Sep 6. PMCID: PMC3232281

Liu SM, Lee DH, Sullivan JM, Chung D, Jaeger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. J Clin Invest. 2011 Nov 1;121(11):4303-10. PMCID: PMC3204832

Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Frantz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous tissue inflammation. Immunity. 2011 Dec 23;35(6):986-96. Epub 2011 Dec 15. PMCID: PMC3422678

Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19001-6. Epub 2011 Nov 3. PMCID: PMC3223445

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